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Wednesday, November 01, 2006

Still Waiting for Personalized Medicine

Pharmacogenomics promises to let doctors choose drugs and dosages based on tests of your genetic profile. But just try taking a test.

By Emily Singer

Nausea, fatigue, dizziness, dry mouth, insomnia. For people like me, who seem susceptible to every side effect possible, the tiny type on ads for new drugs is required reading. NyQuil puts me into a half-conscious delirium. Codeine makes me throw up. And back in college, when my doctor prescribed Wellbutrin to help me quit smoking, I experienced blurred vision and the worst headaches of my life.

Given that my troubled history with medication is shared by my mother and sister, I have long suspected a genetic basis for my sensitivity. So like many others, I have over the last few years eagerly anticipated the benefits of pharmacogenomics--a field whose researchers aim to let doctors tailor prescriptions to their patients' genetic makeups. It's one of the most tantalizing promises of the genomic era: quick and easy tests that tell you which drugs to take or what dose is right for you.

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